Klez.H, which was first detected on April 15, now affects one in every 300 e-mails, said UK-based MessageLabs on Monday. The company has traced 775,000 copies of the virus so far.
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I've posted news about this virus in the past, but this program is now the most wide-spread virus of all-time. Read CNN's report.
If you get hit by this virus, Symantec also has a removal tool you can run which will help you remove it. Make sure to read the insctructions on the page with the tool.
As you already know, the best way to protect yourself is to know what every email attachment contains before you open it, but that's not always an option. About 99% of viruses can be completely removed from the system with a simply hard drive reformatting. A virus is not the end of your PC.