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style="Margin:0;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0;padding:0;text-align:left"><table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="16px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;hyphens:auto;line-height:16px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table> <h4 class="text-center" style="-moz-hyphens:none;-webkit-hyphens:none;Margin:0;Margin-bottom:10px;color:#fff;font-family:Montserrat,Arial,sans-serif;font-size:18px;font-weight:400;hyphens:none;line-height:22px;margin:0;margin-bottom:10px;padding:0;text-align:center;text-transform:uppercase;word-break:none;word-wrap:normal">News From INSIGHTEC</h4><h5 class="text-center" style="-moz-hyphens:none;-webkit-hyphens:none;Margin:0;Margin-bottom:10px;color:#fff;font-family:Montserrat,Arial,sans-serif;font-size:14px;font-weight:500;hyphens:none;line-height:18px;margin:0;margin-bottom:0;padding:0;text-align:center;word-break:none;word-wrap:normal">Transmitted by PR Newswire for Journalists on <span class="prevent-break" style="display:inline-block">May 14, 2018 08:00 AM EST </span></h5></th><th class="expander" style="Margin:0;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0;padding:0!important;text-align:left;visibility:hidden;width:0"></th></tr></table></th></tr></tbody></table><table class="row header" style="background:#e5f2f3;border-collapse:collapse;border-spacing:0;display:table;padding:0;position:relative;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><th class="small-12 large-12 columns first last" style="Margin:0 auto;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0 auto;padding:0;padding-bottom:0;padding-left:30px;padding-right:30px;text-align:left;width:570px"><table style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tr style="padding:0;text-align:left;vertical-align:top"><th style="Margin:0;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0;padding:0;text-align:left"> <table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="24px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:24px;font-weight:400;hyphens:auto;line-height:24px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table> <h1 style="Margin:0;Margin-bottom:10px;color:#4D4E53;font-family:Montserrat,Arial,sans-serif;font-size:20px;font-weight:500;line-height:28px;margin:0;margin-bottom:0;padding:0;text-align:left;word-wrap:normal">INSIGHTEC Submits Pre-market Approval to Japanese PMDA of MR-guided Focused Ultrasound Surgery for Treatment of Parkinson's Disease</h1> <table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="24px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:24px;font-weight:400;hyphens:auto;line-height:24px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table> </th><th class="expander" style="Margin:0;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0;padding:0!important;text-align:left;visibility:hidden;width:0"></th></tr></table></th> </tr></tbody></table> <table class="row content" style="background:#fff;border-collapse:collapse;border-spacing:0;display:table;padding:0;position:relative;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><th class="small-12 large-12 columns first last" style="Margin:0 auto;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0 auto;padding:0;padding-bottom:16px;padding-left:30px;padding-right:30px;text-align:left;width:570px"><table style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tr style="padding:0;text-align:left;vertical-align:top"><th style="Margin:0;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0;padding:0;text-align:left"> <table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="24px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:24px;font-weight:400;hyphens:auto;line-height:24px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table><p><span class="xn-location">HAIFA, Israel</span>, <span class="xn-chron">May 14, 2018</span> /PRNewswire/ --</p>
<p>INSIGHTEC®, a global medical technology innovator of incisionless surgery, today announced that it has submitted a Pre-Market Approval (PMA) to the Japanese Pharmaceuticals and Medical Devices Agency (PMDA) for its Exablate Neuro⢠(Exablate 4000) device for treating advanced Parkinson's Disease patients suffering from mobility, rigidity or dyskinesia effects.</p>
<p>The Exablate Neuro, which uses focused ultrasound together with MR imaging to treat deep within the brain with no incisions, is intended to improve motor function and reduce dyskinesia. Dyskinesia is one of the debilitating symptoms that presents as uncontrolled, involuntary movement of the arms and/or legs. Dyskinesia often occurs as a side effect of medication in Parkinson's Disease patients.</p>
<p>"INSIGHTEC is committed to supporting research that extends the applications and potential of focused ultrasound, to improve the lives of people living with Parkinson's disease with a much less invasive approach than conventional surgery," commented Maurice R. Ferré MD, INSIGHTEC'S CEO and Chairman of the Board of Directors.</p>
<p>The Exablate Neuro is currently approved by MHLW to treat medication-refractory essential tremor. There are currently seven medical institutions in <span class="xn-location">Japan</span> performing the incisionless focused ultrasound treatment for essential tremor on a routine basis.</p>
<p><b>About INSIGHTEC</b> </p>
<p>INSIGHTEC is a global medical technology innovator transforming patient lives through incisionless brain surgery with MR-guided focused ultrasound. Research for future applications in the neuroscience space is underway in partnership with leading academic and medical institutions. INSIGHTEC is headquartered in <span class="xn-location">Haifa, Israel</span>, and <span class="xn-location">Miami</span>, with offices in <span class="xn-location">Dallas</span>, <span class="xn-location">Tokyo</span> and <span class="xn-location">Shanghai</span>.</p>
<p>For more information, please visit: <a href="http://email.prnewswire.com/wf/click?upn=TwIh0OIjG8BOSB67uKqqj-2Fb7A2CDKOaxE3-2B21rYZzmk-3D_q1N77mbql2CxsoEfo2fFiZ6dnlev64IGUSa1KT1DDw1MuprZmQ6aap9NY9k0Le75mwoo-2BieSSVnM5gbsCWrwFADBsb0O8gLAs2Sv8h6chY-2B8zN-2BXR6zUq3RD-2FEoyk8RcbnsTyLgUYofu47fpEu0AoWilm-2FG-2FP0Sg-2FgxDFurGscF4ZwiB-2BCfE6bpaCedGPytppuDx1-2BWEJ55emLWHU3lZbLBBCWdqov9Kml-2FyJ9B9SJJuCAn3YTKLT5w2crbeBNX8q-2FF-2FqzWILbvC1-2FwEwCbkuaK0gH74ifo5Xu3-2BmqoAHq5IZaGxiQR31K9ACPqPT8U721kyBTYvHDXEX0KtdIsGGg-3D-3D" rel="nofollow">http://www.insightec.com</a> <br> </p>
<p><b>Media Contacts:</b><br> <span class="xn-person">Laura Vinci</span><br> CooperKatz & Company, Inc. for INSIGHTEC<br> <a href="mailto:lvinci@cooperkatz.com" rel="nofollow">lvinci@cooperkatz.com</a><br> 917-595-3095<br> </p><table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="8px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:8px;font-weight:400;hyphens:auto;line-height:8px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table> <table class="button medium expand" style="Margin:0 0 16px 0;border-collapse:collapse;border-spacing:0;margin:0 0 16px 0;padding:0;text-align:left;vertical-align:top;width:100%!important"><tr 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style="-moz-hyphens:none;-webkit-hyphens:none;Margin:0;Margin-bottom:10px;color:#fff;font-family:Montserrat,Arial,sans-serif;font-size:18px;font-weight:400;hyphens:none;line-height:22px;margin:0;margin-bottom:10px;padding:0;text-align:center;text-transform:uppercase;word-break:none;word-wrap:normal">News From INSIGHTEC</h4><h5 class="text-center" style="-moz-hyphens:none;-webkit-hyphens:none;Margin:0;Margin-bottom:10px;color:#fff;font-family:Montserrat,Arial,sans-serif;font-size:14px;font-weight:500;hyphens:none;line-height:18px;margin:0;margin-bottom:0;padding:0;text-align:center;word-break:none;word-wrap:normal">Transmitted by PR Newswire for Journalists on <span class="prevent-break" style="display:inline-block">May 14, 2018 08:00 AM EST </span></h5></th><th class="expander" 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style="Margin:0;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0;padding:0;text-align:left"> <table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="24px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:24px;font-weight:400;hyphens:auto;line-height:24px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table> <h1 style="Margin:0;Margin-bottom:10px;color:#4D4E53;font-family:Montserrat,Arial,sans-serif;font-size:20px;font-weight:500;line-height:28px;margin:0;margin-bottom:0;padding:0;text-align:left;word-wrap:normal">INSIGHTEC Submits Pre-market Approval to Japanese PMDA of MR-guided Focused Ultrasound Surgery for Treatment of Parkinson's Disease</h1> <table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="24px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:24px;font-weight:400;hyphens:auto;line-height:24px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table> </th><th class="expander" style="Margin:0;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:16px;font-weight:400;line-height:1.3;margin:0;padding:0!important;text-align:left;visibility:hidden;width:0"></th></tr></table></th> </tr></tbody></table> <table class="row content" 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style="padding:0;text-align:left;vertical-align:top"><td height="24px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:24px;font-weight:400;hyphens:auto;line-height:24px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table><p><span class="xn-location">HAIFA, Israel</span>, <span class="xn-chron">May 14, 2018</span> /PRNewswire/ --</p>
<p>INSIGHTEC®, a global medical technology innovator of incisionless surgery, today announced that it has submitted a Pre-Market Approval (PMA) to the Japanese Pharmaceuticals and Medical Devices Agency (PMDA) for its Exablate Neuro⢠(Exablate 4000) device for treating advanced Parkinson's Disease patients suffering from mobility, rigidity or dyskinesia effects.</p>
<p>The Exablate Neuro, which uses focused ultrasound together with MR imaging to treat deep within the brain with no incisions, is intended to improve motor function and reduce dyskinesia. Dyskinesia is one of the debilitating symptoms that presents as uncontrolled, involuntary movement of the arms and/or legs. Dyskinesia often occurs as a side effect of medication in Parkinson's Disease patients.</p>
<p>"INSIGHTEC is committed to supporting research that extends the applications and potential of focused ultrasound, to improve the lives of people living with Parkinson's disease with a much less invasive approach than conventional surgery," commented Maurice R. Ferré MD, INSIGHTEC'S CEO and Chairman of the Board of Directors.</p>
<p>The Exablate Neuro is currently approved by MHLW to treat medication-refractory essential tremor. There are currently seven medical institutions in <span class="xn-location">Japan</span> performing the incisionless focused ultrasound treatment for essential tremor on a routine basis.</p>
<p><b>About INSIGHTEC</b> </p>
<p>INSIGHTEC is a global medical technology innovator transforming patient lives through incisionless brain surgery with MR-guided focused ultrasound. Research for future applications in the neuroscience space is underway in partnership with leading academic and medical institutions. INSIGHTEC is headquartered in <span class="xn-location">Haifa, Israel</span>, and <span class="xn-location">Miami</span>, with offices in <span class="xn-location">Dallas</span>, <span class="xn-location">Tokyo</span> and <span class="xn-location">Shanghai</span>.</p>
<p>For more information, please visit: <a href="http://email.prnewswire.com/wf/click?upn=TwIh0OIjG8BOSB67uKqqj-2Fb7A2CDKOaxE3-2B21rYZzmk-3D_q1N77mbql2CxsoEfo2fFiZ6dnlev64IGUSa1KT1DDw1MuprZmQ6aap9NY9k0Le75mwoo-2BieSSVnM5gbsCWrwFADBsb0O8gLAs2Sv8h6chY-2B8zN-2BXR6zUq3RD-2FEoyk8RcbnsTyLgUYofu47fpEu0AoWilm-2FG-2FP0Sg-2FgxDFurGscF4ZwiB-2BCfE6bpaCedGPytppuDx1-2BWEJ55emLWHU3lZbLBBCWdqov9Kml-2FyJ9B9SJJuCAn3YTKLT5w2crbeBNX8q-2FF-2FqzWILbvC1-2FwEwCbkuaK0gH74ifo5Xu3-2BmqoAHq5IZaGxiQR31K9ACPqPT8U721kyBTYvHDXEX0KtdIsGGg-3D-3D" rel="nofollow">http://www.insightec.com</a> <br> </p>
<p><b>Media Contacts:</b><br> <span class="xn-person">Laura Vinci</span><br> CooperKatz & Company, Inc. for INSIGHTEC<br> <a href="mailto:lvinci@cooperkatz.com" rel="nofollow">lvinci@cooperkatz.com</a><br> 917-595-3095<br> </p><table class="spacer" style="border-collapse:collapse;border-spacing:0;padding:0;text-align:left;vertical-align:top;width:100%"><tbody><tr style="padding:0;text-align:left;vertical-align:top"><td height="8px" style="-moz-hyphens:auto;-webkit-hyphens:auto;Margin:0;border-collapse:collapse!important;color:#0a0a0a;font-family:Montserrat,Arial,sans-serif;font-size:8px;font-weight:400;hyphens:auto;line-height:8px;margin:0;mso-line-height-rule:exactly;padding:0;text-align:left;vertical-align:top;word-wrap:break-word"> </td></tr></tbody></table> <table class="button medium expand" style="Margin:0 0 16px 0;border-collapse:collapse;border-spacing:0;margin:0 0 16px 0;padding:0;text-align:left;vertical-align:top;width:100%!important"><tr 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